The more I learn about metabolism, the more I am convinced: we cannot pick out a single mechanism or substance and expect that this will yield major insights. I think, lifestyle is a key factor to staying healthy and fit. This involves healthy diet as well as enough sport or moving around and mental attitude. The sum is much bigger as single components. However, I really appreciate your look at the details and current studies and I read your articles with interest and they enrich my knowledge. Thank you.